Harris & Harris Group, Inc.

ABS MATERIALS, INC. (Private)

ABS Materials, Inc., is developing solutions for remediation of environmental contaminants from groundwater and from produced water, a by-product of the process of extraction of oil and natural gas from in-ground wells. The company uses a proprietary, recyclable glass material that contains nanoscale pores to capture contaminants selectively from water.
www.absmaterials.com

ADESTO TECHNOLOGIES CORPORATION (Private)

Adesto Technologies Corporation is a fabless semiconductor company.
www.adestotech.com

ANCORA PHARMACEUTICALS, INC. (Private)

Ancora Pharmaceuticals Inc., enables synthetic carbohydrate-based product discovery and development utilizing its state-of-the-art carbohydrate synthesis capability, which is based on technology originally developed at the Massachusetts Institute of Technology (M.I.T.). The company is applying its synthesis technology both to internal drug development programs and strategic collaborations within the pharmaceutical and biotechnology sector.
www.ancorapharma.com

BIOVEX GROUP, INC. (Acq. by Amgen (NASDAQ: AMGN))

BioVex Group, Inc., was a clinical stage company developing new generation biologics for the treatment and prevention of cancer and infectious disease. The company was acquired by Amgen, Inc., on March 4, 2011.
www.biovex.com

BRIDGELUX, INC. (Private)

BridgeLux, Inc. develops high-power indium gallium nitride light emitting diodes that are used in various solid state lighting, mobile appliance, signage, and automotive applications.
www.bridgelux.com

CAMBRIOS TECHNOLOGY CORPORATION (Private)

Cambrios Technologies Corporation develops electronic materials for the display industry. The company's first product, a directly patternable, wet-processable transparent conductive film, is designed as a replacement for indium tin oxide (ITO), which is the current industry-standard transparent conductor material.
www.cambrios.com

CHAMPIONS ONCOLOGY, INC. (Public - OTC:CSBR)

Champions Oncology Inc. develops advanced technology solutions to personalize the development and use of oncology drugs. Champions Tumorgraft™ (CTG) Technology Platform is a novel approach based upon the implantation of primary human tumors in immune-deficient mice followed by propagation of the resulting engraftments, or Tumorgrafts™, in a manner that preserves the biological characteristics of the original human tumor.
www.championsoncology.com

CONTOUR ENERGY SYSTEMS, INC. (Private)

Contour Energy Systems, Inc., (formerly CFX Battery, Inc.), develops primary and rechargable batteries enabled by its proprietary fluorine-based battery chemistries, nanomaterials science and manufacturing processes.
www.contourenergy.com

COBALT TECHNOLOGIES (Private)

Cobalt Technologies is using its current portfolio of technologies to advance the commercial production of biobutanol. By optimizing fermentation productivity, yield, and titer, Cobalt is making biobutanol a viable and economic transportation fuel.
www.cobalttech.com

CRYSTAL IS, INC. (Private)

Crystal IS, Inc., develops methods to produce large, high-quality, single- crystal substrates of aluminum nitride (AlN) for use in the nitride semiconductor industry. These substrates are used in the production of high-power, high-temperature, and optoelectronic devices such as blue and ultraviolet lasers.
www.crystal-is.com

D-WAVE SYSTEMS, INC. (Private)

D-Wave Systems, Inc., develops high-performance quantum computing systems for commercial use in logistics, bioinformatics, life and physical sciences, quantitative finance and electronic design automation.
www.dwavesys.com

ENSEMBLE THERAPEUTICS CORPORATION (Private)

Ensemble Therapeutics Corporation develops therapeutics and bioassays using its proprietary DNA-Programmed Chemistry™ (DPC™) platform. DPC provides spatial control of chemical reactivity, enabling the synthesis of diverse compounds for use in drug discovery and biodetection.
www.ensembletx.com

ENUMERAL TECHNOLOGIES, INC. (Private)

Enumeral Technologies uses its proprietary microengraving technology to address high-value opportunities in immunology including therapeutic discovery, immune profiling and personalized medicine.
www.enumeral.com

GEO SEMICONDUCTOR, INC. (Private)

GEO Semiconductor, Inc., develops programmable, high performance, video and geometry processing solutions. Its technology enables real-time correction of non-uniformities in brightness and color in LED-backlit displays and distortions in images captured by smartphone cameras. Correction of these issues using digital processing solutions reduces the need for expensive optics and may lower the cost and improve the performance of displays and smartphone cameras.
www.geosemi.com

INNOVALIGHT, INC. (Acq. by DuPont (NYSE:DD))

Innovalight, Inc., developed low-cost, high-performance renewable energy products based on silicon nanotechnology.
www.innovalight.com

KOVIO, INC. (Private)

Kovio, Inc., develops semiconductor products using thin film technologies, printed electronics and nanoparticle inks.
www.kovio.com

LASER LIGHT ENGINES, INC. (Private)

Laser Light Engines is developing solid state light sources for digital cinema and other large venue projectors that the company expects to consume up to 75% less power than traditional arc lamps. The company will manufacture a light source module that can be incorporated in a standard digital cinema projector. The source is expected to be brighter, more energy efficient and more reliable than an arc lamp. It is also expected to have a wider color gamut and enable color balance control.
www.laserlightengines.com

MERSANA THERAPEUTICS, INC. (Private)

Mersana Therapeutics, Inc., is a research-based company developing fully biodegradable nanoscopic drug delivery vehicles based on proprietary molecular constructs and "biological stealth" materials.
www.mersana.com

METABOLON, INC. (Private)

Metabolon, Inc., uses a proprietary technology platform in metabolomics to map changes in metabolic pathways. Measurement of the spectrum of cellular biochemical changes and the subsequent mapping of these changes to metabolic pathways permits a direct understanding of a disease. This information is used for the discovery and development of drugs, the identification of biomarkers and the early diagnosis of disease states.
www.metabolon.com

MOLECULAR IMPRINTS, INC. (Private)

Molecular Imprints, Inc., develops and manufactures nano-lithography systems for high resolution and for 3-dimensional pattern replication. The company has commercialized a new and unique Step and Flash Imprint Lithography technology (S-FILTM), which is a simple step and repeat, room temperature, low pressure, nano-imprint process that has demonstrated sub-20 nanometer resolution.
www.molecularimprints.com

NANOSYS, INC. (Private)

Nanosys, Inc., is developing nanotechnology-enabled systems incorporating novel and patent-protected zero and one-dimensional nanometer-scale materials such as nanowires, nanotubes and nanodots (quantum dots).
www.nanosysinc.com

NANTERO, INC. (Private)

Nantero, Inc., is developing a high-density, nonvolatile random access memory (NRAM) chip using nanotechnology.
www.nantero.com

NEXTREME THERMAL SOLUTIONS, INC. (Private)

Nextreme Thermal Solutions, Inc., designs and manufactures micro-scale thermal and power management products for the semiconductor, photonics, consumer, automotive and defense/aerospace industries. The company has embedded cooling and power generation capabilities into the widely accepted copper pillar bumping process used in high-volume electronic packaging.
www.nextremethermal.com

NEOPHOTONICS CORPORATION (Public - NYSE: NPTN)

NeoPhotonics Corporation develops and manufactures advanced planar optical devices by monolithically integrating active and passive optical materials using the company's proprietary nanomaterials-based process solutions.
www.neophotonics.com

SIONYX, INC. (Private)

SiOnyx, Inc., develops silicon-based optoelectronic products enabled by its proprietary, "Black Silicon."
www.sionyx.com

SOLAZYME, INC. (Public - NASDAQ:SZYM)

Solazyme, Inc., is a biotechnology company focused on synthetic biology for the renewable bioproduction of fuels, industrial oleochemicals, and health and wellness ingredients from marine microbes.
www.solazyme.com

TETRAVITAE BIOSCIENCE, INC. (Private)

Tetravitae Bioscience develops alternative fuels through biomass conversion. Tetravitae's initial focus is on the production of biobutanol at commercial yield, using a proprietary, continuous fermentation process, which incorporates a patented, genetically enhanced strain of bacteria.
www.tetravitae.com

XRADIA, INC. (Private)

Xradia designs and manufactures a suite of ultra high resolution 3D x-ray microscopes and fluorescence imaging systems for non-destructive imaging of embedded internal structures.
www.xradia.com


Portfolio



ABS MATERIALS, INC. (Private) ABS Materials, Inc., is developing solutions for remediation of environmental contaminants from groundwater and from produced water, a by-product of the process of extraction of oil and natural gas from in-ground wells. The company uses a proprietary, recyclable glass material that contains nanoscale pores to capture contaminants selectively from water. www.absmaterials.com ADESTO TECHNOLOGIES CORPORATION (Private) Adesto Technologies Corporation is a fabless semiconductor company. www.adestotech.com ANCORA PHARMACEUTICALS, INC. (Private) Ancora Pharmaceuticals Inc., enables synthetic carbohydrate-based product discovery and development utilizing its state-of-the-art carbohydrate synthesis capability, which is based on technology originally developed at the Massachusetts Institute of Technology (M.I.T.). The company is applying its synthesis technology both to internal drug development programs and strategic collaborations within the pharmaceutical and biotechnology sector. www.ancorapharma.com BIOVEX GROUP, INC. (Acq. by Amgen (NASDAQ: AMGN)) BioVex Group, Inc., was a clinical stage company developing new generation biologics for the treatment and prevention of cancer and infectious disease. The company was acquired by Amgen, Inc., on March 4, 2011. www.biovex.com BRIDGELUX, INC. (Private) BridgeLux, Inc. develops high-power indium gallium nitride light emitting diodes that are used in various solid state lighting, mobile appliance, signage, and automotive applications. www.bridgelux.com CAMBRIOS TECHNOLOGY CORPORATION (Private) Cambrios Technologies Corporation develops electronic materials for the display industry. The company's first product, a directly patternable, wet-processable transparent conductive film, is designed as a replacement for indium tin oxide (ITO), which is the current industry-standard transparent conductor material. www.cambrios.com CHAMPIONS ONCOLOGY, INC. (Public - OTC:CSBR) Champions Oncology Inc. develops advanced technology solutions to personalize the development and use of oncology drugs. Champions Tumorgraft™ (CTG) Technology Platform is a novel approach based upon the implantation of primary human tumors in immune-deficient mice followed by propagation of the resulting engraftments, or Tumorgrafts™, in a manner that preserves the biological characteristics of the original human tumor. www.championsoncology.com CONTOUR ENERGY SYSTEMS, INC. (Private) Contour Energy Systems, Inc., (formerly CFX Battery, Inc.), develops primary and rechargable batteries enabled by its proprietary fluorine-based battery chemistries, nanomaterials science and manufacturing processes. www.contourenergy.com COBALT TECHNOLOGIES (Private) Cobalt Technologies is using its current portfolio of technologies to advance the commercial production of biobutanol. By optimizing fermentation productivity, yield, and titer, Cobalt is making biobutanol a viable and economic transportation fuel. www.cobalttech.com CRYSTAL IS, INC. (Private) Crystal IS, Inc., develops methods to produce large, high-quality, single- crystal substrates of aluminum nitride (AlN) for use in the nitride semiconductor industry. These substrates are used in the production of high-power, high-temperature, and optoelectronic devices such as blue and ultraviolet lasers. www.crystal-is.com D-WAVE SYSTEMS, INC. (Private) D-Wave Systems, Inc., develops high-performance quantum computing systems for commercial use in logistics, bioinformatics, life and physical sciences, quantitative finance and electronic design automation. www.dwavesys.com ENSEMBLE THERAPEUTICS CORPORATION (Private) Ensemble Therapeutics Corporation develops therapeutics and bioassays using its proprietary DNA-Programmed Chemistry™ (DPC™) platform. DPC provides spatial control of chemical reactivity, enabling the synthesis of diverse compounds for use in drug discovery and biodetection. www.ensembletx.com ENUMERAL TECHNOLOGIES, INC. (Private) Enumeral Technologies uses its proprietary microengraving technology to address high-value opportunities in immunology including therapeutic discovery, immune profiling and personalized medicine. www.enumeral.com GEO SEMICONDUCTOR, INC. (Private) GEO Semiconductor, Inc., develops programmable, high performance, video and geometry processing solutions. Its technology enables real-time correction of non-uniformities in brightness and color in LED-backlit displays and distortions in images captured by smartphone cameras. Correction of these issues using digital processing solutions reduces the need for expensive optics and may lower the cost and improve the performance of displays and smartphone cameras. www.geosemi.com INNOVALIGHT, INC. (Acq. by DuPont (NYSE:DD)) Innovalight, Inc., developed low-cost, high-performance renewable energy products based on silicon nanotechnology. www.innovalight.com KOVIO, INC. (Private) Kovio, Inc., develops semiconductor products using thin film technologies, printed electronics and nanoparticle inks. www.kovio.com LASER LIGHT ENGINES, INC. (Private) Laser Light Engines is developing solid state light sources for digital cinema and other large venue projectors that the company expects to consume up to 75% less power than traditional arc lamps. The company will manufacture a light source module that can be incorporated in a standard digital cinema projector. The source is expected to be brighter, more energy efficient and more reliable than an arc lamp. It is also expected to have a wider color gamut and enable color balance control. www.laserlightengines.com MERSANA THERAPEUTICS, INC. (Private) Mersana Therapeutics, Inc., is a research-based company developing fully biodegradable nanoscopic drug delivery vehicles based on proprietary molecular constructs and "biological stealth" materials. www.mersana.com METABOLON, INC. (Private) Metabolon, Inc., uses a proprietary technology platform in metabolomics to map changes in metabolic pathways. Measurement of the spectrum of cellular biochemical changes and the subsequent mapping of these changes to metabolic pathways permits a direct understanding of a disease. This information is used for the discovery and development of drugs, the identification of biomarkers and the early diagnosis of disease states. www.metabolon.com MOLECULAR IMPRINTS, INC. (Private) Molecular Imprints, Inc., develops and manufactures nano-lithography systems for high resolution and for 3-dimensional pattern replication. The company has commercialized a new and unique Step and Flash Imprint Lithography technology (S-FILTM), which is a simple step and repeat, room temperature, low pressure, nano-imprint process that has demonstrated sub-20 nanometer resolution. www.molecularimprints.com NANOSYS, INC. (Private) Nanosys, Inc., is developing nanotechnology-enabled systems incorporating novel and patent-protected zero and one-dimensional nanometer-scale materials such as nanowires, nanotubes and nanodots (quantum dots). www.nanosysinc.com NANTERO, INC. (Private) Nantero, Inc., is developing a high-density, nonvolatile random access memory (NRAM) chip using nanotechnology. www.nantero.com NEXTREME THERMAL SOLUTIONS, INC. (Private) Nextreme Thermal Solutions, Inc., designs and manufactures micro-scale thermal and power management products for the semiconductor, photonics, consumer, automotive and defense/aerospace industries. The company has embedded cooling and power generation capabilities into the widely accepted copper pillar bumping process used in high-volume electronic packaging. www.nextremethermal.com NEOPHOTONICS CORPORATION (Public - NYSE: NPTN) NeoPhotonics Corporation develops and manufactures advanced planar optical devices by monolithically integrating active and passive optical materials using the company's proprietary nanomaterials-based process solutions. www.neophotonics.com SIONYX, INC. (Private) SiOnyx, Inc., develops silicon-based optoelectronic products enabled by its proprietary, "Black Silicon." www.sionyx.com SOLAZYME, INC. (Public - NASDAQ:SZYM) Solazyme, Inc., is a biotechnology company focused on synthetic biology for the renewable bioproduction of fuels, industrial oleochemicals, and health and wellness ingredients from marine microbes. www.solazyme.com TETRAVITAE BIOSCIENCE, INC. (Private) Tetravitae Bioscience develops alternative fuels through biomass conversion. Tetravitae's initial focus is on the production of biobutanol at commercial yield, using a proprietary, continuous fermentation process, which incorporates a patented, genetically enhanced strain of bacteria. www.tetravitae.com XRADIA, INC. (Private) Xradia designs and manufactures a suite of ultra high resolution 3D x-ray microscopes and fluorescence imaging systems for non-destructive imaging of embedded internal structures. www.xradia.com

Portfolio