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Ensemble Discovery Announces Collaboration With Pfizer

Shareholders of Harris & Harris Group may be interested to know that Ensemble Discovery Corporation and Pfizer Inc. have initiated a strategic alliance to develop drug candidates of a novel class against a number of high-value pharmaceutical targets using Ensemble's proprietary drug discovery platforms and Ensemblin™ compound libraries to discover and advance drug candidates. Pfizer will provide upfront and research payments to Ensemble and will have the right to develop and commercialize any products arising from the collaboration. In addition, Ensemble will receive development milestones plus royalties based on worldwide sales of any drugs emerging from the alliance and commercialized by Pfizer. You may view Ensemble's press release at http://www.ensemblediscovery.com/news/pr20100106.pdf.

Harris & Harris Group is an investor in privately held Ensemble Discovery Corporation.

Harris & Harris Group is a publicly traded venture capital company that invests in nanotechnology and microsystems. Detailed information about Harris & Harris Group and its holdings, including articles on nanotechnology, cleantech and venture capital, can be found on its website at www.HHVC.com.

This news release may contain statements of a forward-looking nature relating to future events. These forward-looking statements are subject to the inherent uncertainties in predicting future results and conditions. These statements reflect the Company's current beliefs, and a number of important factors could cause actual results to differ materially from those expressed in this news release. Please see the Company's Annual Report on Form 10-K for the fiscal year ended December 31, 2008, as well as subsequent filings, filed with the Securities and Exchange Commission for a more detailed discussion of the risks and uncertainties associated with the Company's business, including but not limited to the risks and uncertainties associated with venture capital investing and other significant factors that could affect the Company's actual results. Except as otherwise required by Federal securities laws, the Company undertakes no obligation to update or revise these forward-looking statements to reflect new events or uncertainties. The references to the websites www.HHVC.com and www.ensemblediscovery.com have been provided as a convenience, and the information contained on such websites is not incorporated by reference into this news release. Harris & Harris Group is not responsible for the contents of third party websites.

CONTACT: DOUGLAS W. JAMISON

TEL. NO. (212) 582-0900

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