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Ensemble Discovery Corporation and Roche Extend Collaboration

Shareholders of Harris & Harris Group, Inc., may be interested to read the press release issued by Ensemble Discovery Corporation announcing that it has extended its collaboration with Roche to apply its proprietary diagnostic assays in human clinical studies to analyze combinations of Epidermal Growth Factor Receptors present in cancer tissues. The press release may be viewed at http://www.businesswire.com/portal/site/home/permalink/?ndmViewId=news_view&newsId=20081112005769&newsLang=en.

Harris & Harris Group is an investor in privately held Ensemble Discovery.

Harris & Harris Group is a publicly traded venture capital company that invests in tiny technology, including nanotechnology, microsystems and microelectromechanical systems (MEMS). A growing percentage of the Company's portfolio consists of companies developing cleantech solutions.

Detailed information about Harris & Harris Group and its holdings can be found on its website at www.TinyTechVC.com.

This news release may contain statements of a forward-looking nature relating to future events. These forward-looking statements are subject to the inherent uncertainties in predicting future results and conditions. These statements reflect the Company's current beliefs, and a number of important factors could cause actual results to differ materially from those expressed in this news release. Please see the Company's Annual Report on Form 10-K for the fiscal year ended December 31, 2007, the Company's report on Form 10-Q for the quarter ended September 30, 2008 and subsequent filings, filed with the Securities and Exchange Commission for a more detailed discussion of the risks and uncertainties associated with the Company's business, including but not limited to the risks and uncertainties associated with venture capital investing and other significant factors that could affect the Company's actual results. Except as otherwise required by Federal securities laws, Harris & Harris Group, Inc., undertakes no obligation to update or revise these forward-looking statements to reflect new events or uncertainties. The reference to the websites www.TinyTechVC.com and www.businesswire.com has been provided as a convenience, and the information contained on such websites is not incorporated by reference into this news release. Harris & Harris Group is not responsible for the contents of third party websites or press releases.

CONTACT: DANIEL B. WOLFE

TEL. NO. (212) 582-0900

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